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Viagra: How It Works

Viagra is a widely recognized branded product, the active ingredient in which is sildenafil.

viagra for men

This active ingredient is famous for its ability to inhibit the enzyme called PDE5.

The action of this enzyme is negative for cGMP responsible for relaxation of smooth muscles, including the penile ones.

Inhibition of PDE5 makes cGMP levels grow. As a result, the penile blood vessels dilate.

The substantial elevations in PDE5 concentrations are typical not only for the penis, but also for the other parts of the body. They include but are not limited to retina and lungs.

Viagra can effectively lower PDE5 levels.

Advantages

  • Viagra is the top-ranked product for erectile dysfunction treatment.
  • The medication doesn’t work if a man is not sexually aroused.
  • It takes from 30 to 60 minutes to start feeling the medication action. However, the oral medication administration is also possible 4 hours before sexual intercourse.

Disadvantages

Men between 18-60 years old can become the Viagra users. These men have to be healthy. They shouldn’t use any medications. If you meet these criteria, you may still face the following adverse effects:

  • Headache, digestive upset, blush, back pain, muscle pain, and impairment of vision are the most widespread adverse effects.
  • Hypotension, nasal stuffiness, rhinorrhea, sleeplessness, and epistaxis belong to the less common adverse effects.
  • Sudden loss of vision is a rare but possible adverse effect. It happens if the optic nerve doesn’t get enough blood supply. The men over 50 years old, the patients with hypertension, diabetes, cardiovascular disorders, eye disorders, and high cholesterol levels, as well as the smokers run a higher risk to experience this adverse effect.
  • Priapism is a rare but possible adverse effect. This adverse effect manifests itself as a long-lasting painful erection. Such a medical condition requires the instant doctor consultation.
  • The medication is contraindicated for the men with liver disorders, kidney disorders, haemorrhagic diseases, blood disorders, chest pain, angina, gastric ulcer, Peyronie’s disease, and a range of eye diseases.
  • The patients shouldn’t combine the ED medication with hypertension medications, HIV medications, herbal products, some antifungal drugs, some antibiotics, as well as a range of the medications for treating prostate diseases.
  • Now it’s impossible to find Viagra generics on the U.S. market.

In brief, old men, men suffering from diabetes, cardiovascular diseases, liver disorders, kidney disorders, and convulsionary attacks, as well as men who undergo pharmaceutical treatment have to avoid sildenafil because of a high risk of adverse effects.

 

 

Bottom Line

Viagra is a medication that cures impotence. This medication can’t help without sexual arousal. Gastric disturbance, blush, and headache are in the list of the most common adverse effects.

Recommendations

  • Viagra has to be orally administered only once per day.
  • The daily medication dose typically doesn’t exceed 50 mg. But the dose may also vary between 25 mg and 100 mg. It’s necessary to take the ED pill approximately 60 minutes before sexual intercourse. The medication can still be administered from 30 minutes to 4 hours before sexual intercourse. Don’t take more than the prescribed dose.
  • The medication interacts with grapefruit and grapefruit juice. Never combine them.
  • Consultation with the doctor is obligatory before starting any treatment. If you have any health condition that makes it impossible to use a particular ED drug, the doctor will select a safe option for you.
  • If any adverse effects occur before, during or after sexual activity after the medication intake, you have to instantly seek medical advice.
  • Don’t combine Viagra with nitroglycerin and other nitrate medications. Never use the ED medication with party drugs. The combination of these medications may lead to a life-threatening sudden hypotension.
  • Be watchful of the counterfeit medications. Choose only the trustworthy suppliers of the ED drugs.
  • Impairment of erectile function can be the result of excessive alcohol consumption, overeating, chronic stress, smoking, sedentary lifestyle, etc. If you get rid of bad habits and change your lifestyle, you will be able to relieve ED symptoms.
  • Don’t combine sildenafil with natural Viagra alternatives.
  • Viagra can’t be combined with any other ED drugs. Never use this medication with Revatio.
  • Priapism, loss of vision, and allergic reaction require emergency medical care.
  • Don’t consume alcohol with Viagra since this may cause hypotension and have a negative influence on sexual intercourse.

Medication Efficacy

The maximum plasma concentrations of active ingredient are measured 30-120 minutes after the medication intake. The medication becomes effective 30-60 minutes after the intake, providing that a man is sexually aroused.
 

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